Ozan S. Sarıyer

The paper investigates how lamina-associated domains (LADs) act as size-selective steric barriers to limit protein access to the nuclear periphery, providing a biophysical mechanism for gene regulation.

The paper investigates how peripheral heterochromatin tethering influences nuclear mechanical response through simulations and experiments.

The paper models peripheral chromatin as a flexible polymer chain using de Gennes' self-similar carpet theory to explain two experimental observations about chromatin density and molecular exclusion near the nuclear envelope.