Author

Thales Souza Freire

Universidade de São PauloORCID 0000-0001-6086-3818Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Astrid Silvia de WijniD· 1 shared J. Roadnight SheehaniD· 1 shared Ran FriedmaniD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiophysics

Astrid Silvia de WijnORCID

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1 paper

Recent·Most cited

BiophysicsPLoS Computational BiologyPeer-reviewedNov 7, 2024

Beyond IC50 - A computational dynamic model of drug resistance in enzyme inhibition treatment.

J. Roadnight Sheehan, Astrid Silvia de Wijn, Thales Souza Freire, Ran Friedman

The paper develops a computational model to study drug resistance in Abl1 inhibitors for CML, finding that inhibitory reduction prowess better predicts resistance than traditional metrics.

8 citations

humanstatistical model

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