Author

Pierce Eggan

University of WashingtonORCID 0000-0001-6134-4569Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell signaling & trafficking· 2 Assay:fluorescence / live-cell microscopy· 2 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

Sharona E. GordoniD· 2 shared William N. ZagottaiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

2 top collaborators · 1 mutual co-author link

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2 shared papersBiophysics

Sharona E. GordonORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivMar 31, 2025

Domain Coupling in Allosteric Regulation of SthK Measured Using Time-Resolved Transition Metal Ion FRET

Pierce Eggan, Sharona E. Gordon, William N. Zagotta

This study uses time-resolved tmFRET to analyze conformational changes and energetics in the CNBD of SthK, showing that transmembrane domains make the activating conformation more favorable.

2 citations

fluorescence / live-cell microscopymicroscopy & imaging analysis

𝕏 PostBluesky

BiophysicseLifePeer-reviewedJul 17, 2024

Ligand-Coupled Conformational Changes in a Cyclic Nucleotide-Gated Ion Channel Revealed by Time-Resolved Transition Metal Ion FRET

Pierce Eggan, Sharona E. Gordon, William N. Zagotta

This study uses time-resolved tmFRET to analyze conformational changes and energetics in the SthK C-terminal region upon cAMP and cGMP binding, revealing large structural changes with cAMP and partial agonism with cGMP.

13 citations

fluorescence / live-cell microscopymicroscopy & imaging analysis

𝕏 PostBluesky