A PERK/FOXO1 AXIS LINKS DNA DAMAGE TO FIBROBLAST SURVIVAL IN DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS
Lamia Khan, Junquin Wang, Carmanah D. Hunter…·Mohammed S. Osman
This paper identifies a PERK/FOXO1 axis that enables survival of fibroblasts in diffuse cutaneous systemic sclerosis despite DNA damage, and shows that targeting this axis restores apoptosis.