Arjen ten Have

This paper characterizes the BAHD acyltransferase family across 218 land plant species using phylogenomics to identify specificity determining positions and functional annotations.

Seqrutinator identifies and removes non-functional homologue sequences from proteomes to improve multiple sequence alignments in plant superfamilies.

The paper identifies two subfamilies of fungal sedolisins, tripeptidyl peptidases and endopeptidases, and explains their functional diversification through structural and mutational analysis.

The paper identifies substrate binding and specificity as key drivers of functional diversification in eqolisins through molecular dynamics simulations and phylogenetic analysis.

HMMERCTTER improves protein superfamily classification by introducing a reliable score cut-off threshold using high-quality training data and iterative sequence inclusion.