Abhilash Patel

This paper quantifies how resource variation affects biomolecular circuit robustness and shows that negative feedback improves stability in E. coli.

This study examines how resource constraints affect noise in gene regulatory circuits, showing that higher-order models reduce noise and resource limits can minimize stochastic switching in certain circuits.

This study investigates how resource constraints affect stochastic gene expression by modeling mRNA and protein dynamics under ribosomal limitations and identifies sub-Poisson fluctuations and noise minimization.

The paper investigates tradeoffs in RNA thermometer design, finding an inverse relationship between threshold and sensitivity in two-state models and similar constraints in more complex models.

The paper assesses temperature robustness in negative feedback and feedforward loops using experiments and models, finding temperature-dependent changes and parameter regimes that improve robustness.

The paper experimentally investigates amplitude-timescale co-variation in a pulse generating incoherent feedforward loop circuit and finds that larger amplitude pulses have slower rise times.