Derek K. Smith

This paper develops a deep learning tool for automating cell line development, achieving a 36-day workflow for generating high-titer antibody-producing cell lines.

This paper validates OpenCRISPR-1 in CHO cells, achieving ≥70% INDEL efficiency across multiple genes using a 39-day workflow.

The paper develops a Bayesian method to estimate penetrance of disease-associated variants using sparse data and applies it to SCN5A variants in Brugada syndrome.

The paper identifies a proliferative progenitor-like cell subpopulation in postnatal mouse islets that drives β cell expansion through Notch pathway activity.