Leonard Frach

This study investigates whether genetic birthweight predisposition, through direct or indirect effects, is associated with DNA methylation at birth and identifies six methylation sites linked to maternal indirect effects.

The paper describes the curation and initial analysis of molecular genetic and epigenetic data from the TwinLife study, highlighting associations between polygenic scores and attrition, and stability of epigenetic clocks in saliva.

This study identifies functionally relevant CpG clusters in the OXTR gene associated with childhood maltreatment and provides a web tool for future research.

The paper introduces a targeted bisulfite sequencing method for DNA methylation analysis, demonstrating high sensitivity and coverage in large cohorts without finding significant methylation differences between BPD and healthy controls.