Eric Chien-Wei Liao

The paper performs trio-based GWAS on cleft lip subtypes to identify novel genetic loci associated with specific phenotypes.

CranioTrace automates head circumference and cranial shape measurement from neuroimaging, enabling population growth modeling and identifying disease-related growth trajectory shifts.

The paper identifies GRHL1 as an orofacial cleft risk gene by analyzing conserved transcriptional regulatory networks between zebrafish and human periderm using single-cell multiome sequencing and functional validation.

The paper identifies rare variants in PRKCI as a novel cause of Van der Woude syndrome and other peridermopathy features through clinical and functional analyses.

The paper identifies distinct and overlapping roles of dact1 and dact2 in regulating noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial development.

The paper functionally tests ESRP1/2 variants and CTNND1 isoforms in orofacial cleft models, finding some variants are benign and showing CTNND1's role in palatogenesis.

This study generates a conditional Irf6 mouse model to investigate its role in periderm and neural crest development, revealing distinct phenotypes in these lineages.

The paper investigates the impact of low-frequency coding variants on facial shape in Europeans, identifying seven genes associated with facial morphology and showing a specific variant's effect on chin shape.

This study investigates the role of Irf6 and Esrp1/2 in craniofacial development across mouse and zebrafish, identifying their expression patterns and genetic interactions in cleft formation.