SOX9-mediated G1 elongation confers reserve stem cell-associated injury resistance in human intestinal stem cells
Joseph Burclaff, Keith A. Breau, Lauren T Chi, Whitney L. M. DeLoach, Ebenezer A Amare, L. Cooper, Vanessa A. Walcott, Caroline M. Hinesley, M. Dixit, Kaiwen Chen, Mickaël Meyer, Caden W. Sweet, Davis Walker, R. Jarrett Bliton, Cynthia Y. Tang, Scott T. Magness
This study shows SOX9 elongates G1 phase in intestinal stem cells, enhancing injury resistance and stemness, and identifies the INK4A-Rb pathway as a mediator.
bioRxiv · Aug 24, 2026 · PreprintCell Biology