Caden W. Sweet

The paper uses single-nucleus RNA sequencing to analyze intestinal tissues from NEC patients and controls, identifying disease-specific gene expression programs across multiple cell types.

This study shows SOX9 elongates G1 phase in intestinal stem cells, enhancing injury resistance and stemness, and identifies the INK4A-Rb pathway as a mediator.

The paper builds a dictionary of human intestinal organoid responses to 81 secreted niche factors using scRNA-seq, mapping perturbations and identifying cell type-specific pathways in an IBD context.

The paper identifies EPIREGULIN as a niche factor that enables spatial organization in human intestinal organoids, mimicking the native intestine's structure and gene expression.

This study uses scRNA-seq to analyze human intestinal development, identifying cell sources of niche factors and their functional roles in stem cell maintenance.

This study enhances the co-differentiation of intestinal organoids with endothelial cells, showing they share an intestinal-specific transcriptional signature with native cells.