Systems BiologybioRxivPreprint
Integrative Modelling of Signalling Network Dynamics Identifies Cell Type-selective Therapeutic Strategies for FGFR4-driven Cancers
Sung‐Young Shin, Nicole J. Chew, Milad Ghomlaghi…·Roger J. Daly
The paper develops a computational model of FGFR4 signalling to identify cell type-selective combination therapies for FGFR4-driven cancers, revealing AKT and ERK reactivation as key resistance mechanisms.
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