Genomic insights into the mechanism of NK3R antagonists for treatment of menopausal vasomotor symptoms
Katherine S. Ruth, Robin N. Beaumont, Jonathan M. Locke, Jessica Tyrrell, Carolyn J. Crandall, Gareth Hawkes, Timothy M. Frayling, Julia Prague, Kashyap Amratlal Patel, Andrew R. Wood, Michael N. Weedon, Anna Murray
This paper identifies a genetic association between NK3R (TACR3) and menopausal vasomotor symptoms (VMS) using GWAS, while finding no link between rare NK3R variants and VMS despite the efficacy of NK3R antagonists.
medRxiv · May 25, 2022 · PreprintGenetic & Genomic Medicine