This paper conducts a trans-ancestry GWAS of hot flashes, identifies TACR3 as a key genetic target, and finds genetic overlaps with psychiatric disorders.

Communications Medicine · Jan 6, 2026Peer-reviewedGenetic & Genomic Medicine

Genomic insights into the mechanism of NK3R antagonists for treatment of menopausal vasomotor symptoms

Katherine S. Ruth, Robin N. Beaumont, Jonathan M. Locke, Jessica Tyrrell, Carolyn J. Crandall, Gareth Hawkes, Timothy M. Frayling, Julia Prague, Kashyap Amratlal Patel, Andrew R. Wood, Michael N. Weedon, Anna Murray

This paper identifies a genetic association between NK3R (TACR3) and menopausal vasomotor symptoms (VMS) using GWAS, while finding no link between rare NK3R variants and VMS despite the efficacy of NK3R antagonists.

medRxiv · May 25, 2022 · PreprintGenetic & Genomic Medicine

Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

Brian E. Cade, Jiwon Lee, Tamar Sofer, Heming Wang, Man Zhang, Han Chen, Sina A. Gharib, Daniel J. Gottlieb, Xiuqing Guo, Jacqueline M. Lane, Jingjing Liang, Xihong Lin, Hao Mei, Sanjay R. Patel, Shaun Purcell, , Scott E. Devine

The paper reports whole-genome association analyses of sleep-disordered breathing traits in the NHLBI TOPMed program, identifying rare and common variant associations.

Genome Medicine · Aug 26, 2021Peer-reviewedGenetics

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

Pradeep Natarajan, Gina Marie Peloso, Seyedeh Maryam Zekavat, May E. Montasser, Andrea Ganna, Mark D. Chaffin, Amit V. Khera, Wei Zhou, Jonathan M. Bloom, J Engreitz, Jason Ernst, Jeffrey R. O’Connell, Sanni Ruotsalainen, Maris Alver, Ani W Manichaikul, , Sayantan Das

The paper analyzes whole genome sequences from 16,324 individuals to identify genetic variants associated with blood lipid levels and develops a polygenic score for LDL-C.

Nature Communications · Aug 17, 2018Peer-reviewedGenomics