BiochemistryScientific ReportsPeer-reviewed
The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48/p97 ATPase for proteasomal degradation
Hao Li, Haipeng Guan, Tom A. Rapoport
The paper shows that Otu1 removes ubiquitin chains from substrates to enable their transfer from Cdc48 ATPase to proteasome for degradation.
DOI 10.1038/s41598-026-42811-6