Author

Ann Dean

National Institutes of HealthORCID 0000-0001-6558-747XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Assay:ChIP-seq· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Bingning XieiD· 1 shared HeungSun Kwon· 1 shared Ivan V. KrivegaiD· 1 shared Jongjoo LeeiD· 1 shared Juhyun KimiD· 1 shared Lecong ZhouiD· 1 shared Ryan DaleiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 6 mutual co-author links

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1 shared paperGenomics

Bingning XieORCID

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3 papers

Recent·Most cited

Developmental BiologyNucleic Acids ResearchPeer-reviewedJan 22, 2026

LDB1 regulates gene expression and chromatin structure in pluripotency and lineage differentiation

HeungSun Kwon, Juhyun Kim, Lecong Zhou, Ann Dean

This study shows that LDB1 is essential for maintaining pluripotency and supporting differentiation, particularly in erythroblasts, through effects on gene expression and chromatin structure.

3 citations

mousebulk RNA-seq

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GenomicsbioRxivPreprintDec 5, 2023

Noncoding function of super enhancer derived mRNA in modulating neighboring gene expression and TAD interaction

Bingning Xie, Ann Dean

The paper shows that mRNA from a super enhancer can regulate neighboring genes and TAD interactions by affecting chromatin modifications and enhancer activity.

1 citation

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Molecular BiologyCell ReportsPeer-reviewedJun 1, 2017

The LDB1 complex co-opts CTCF for erythroid lineage specific long-range enhancer interactions

Jongjoo Lee, Ivan V. Krivega, Ryan Dale, Ann Dean

The paper shows that the LDB1 complex uses CTCF to create specific long-range enhancer interactions in erythroid cells, activating genes like Car2.

86 citations

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