Doris Marko

This study examines how tenuazonic acid affects immune and intestinal epithelial cells, showing opposing immunomodulatory effects depending on cell type.

This study investigates how Alternaria mycotoxins modulate NF-κB signaling in THP-1 monocytes using in vitro experiments and in silico docking analyses, revealing toxin-specific effects on inflammatory responses.

This study compares the hepatic metabolism of AME, TeA, and ATX-II in rat and human hepatocytes, revealing interspecies differences in clearance and metabolite formation.

This study assesses the endocrine activity of six Alternaria toxins using in vitro assays, finding estrogenic and anti-estrogenic effects in specific compounds.

This study assesses the in vitro genotoxicity of Alternaria toxins using OECD-aligned assays, finding mutagenicity and chromosomal damage for several toxins.

This study investigates the effects of tenuazonic acid on human esophageal cells, showing it induces oxidative stress, DNA damage, mitochondrial changes, and transcriptomic responses.

The paper predicts human internal exposure to alternariol and AME using a PBK model, finding concentrations far below toxic thresholds.

This study compares the hepatic metabolism of altenuene and tentoxin in rat and human hepatocytes, revealing significant interspecies differences in metabolism and clearance.

This study shows that sulfoquinovose is not metabolized by mice or humans but is degraded by gut microbiota, with differences in degradation pathways between mice and humans.