Author

Joseph A. Landsittel

Northwestern UniversityORCID 0000-0001-6586-4924Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:metagenomics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:multiple species· 1 Approach:statistical model· 1

Frequent Co-Authors

Kiseok Keith LeeiD· 2 shared Seppe KuehniD· 2 shared Addison HoweiD· 1 shared Freddy BunburyiD· 1 shared Madhav ManiiD· 1 shared Matthew S. SchmittiD· 1 shared Vincenzo VitelliiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

Kiseok Keith LeeORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintSep 10, 2026

The ecological context of enzymatic variation

Joseph A. Landsittel, Addison Howe, Seppe Kuehn…·Madhav Mani

This study links enzyme sequence variation to functional responses in microbial ecosystems using nitrate reductase as a model, showing predictable sequence-to-activity relationships.

DOI 10.64898/2026.09.09.750510

multiple speciesmetagenomics

𝕏 PostBluesky

MicrobiologybioRxivPreprintMar 3, 2026

Learning functional groups in complex microbiomes

Matthew S. Schmitt, Kiseok Keith Lee, Freddy Bunbury…·Seppe Kuehn

This paper introduces a neural-network based method to identify functional groups in microbiomes, showing it can distill complex communities into few groups that explain community function across different environments.

1 citation

metagenomicsdeep learning

𝕏 PostBluesky