Author

Addison Howe

Northwestern UniversityORCID 0009-0007-3330-9927Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:metagenomics· 1 Organism:multiple species· 1 Approach:statistical model· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Madhav ManiiD· 2 shared Joseph A. LandsitteliD· 1 shared Kiseok Keith LeeiD· 1 shared Seppe KuehniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersBiophysics

Madhav ManiORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintSep 10, 2026

The ecological context of enzymatic variation

Joseph A. Landsittel, Addison Howe, Seppe Kuehn…·Madhav Mani

This study links enzyme sequence variation to functional responses in microbial ecosystems using nitrate reductase as a model, showing predictable sequence-to-activity relationships.

DOI 10.64898/2026.09.09.750510

multiple speciesmetagenomics

𝕏 PostBluesky

Developmental BiologyPhysical Review XPeer-reviewedSep 15, 2025

Learning geometric models for developmental dynamics

Addison Howe, Madhav Mani

The paper develops a framework using neural networks to infer a geometric landscape of cellular differentiation from gene expression data, providing an interpretable model of developmental dynamics.

DOI 10.1103/8vpj-bj7d

bulk RNA-seqdeep learning

𝕏 PostBluesky