Dysfunctional Hippocampal-Prefrontal Network Underlies a Multidimensional Neuropsychiatric Phenotype following Early-Life Seizure
Rafael Naime Ruggiero, Danilo Benette Marques, Matheus Teixeira Rossignoli, Jana Batista De Ross, Tamiris Prizon, Ikaro Jesus Silva Beraldo, Lézio Soares Bueno-Júnior, Ludmyla Kandratavicius, José Eduardo Peixoto-Santos, Cleiton Lopes‐Aguiar, João Pereira Leite
This study investigates the long-term effects of early-life seizures on hippocampal-prefrontal network function and behavior in rats, finding impaired connectivity and altered neurotransmission linked to cognitive and psychiatric-like symptoms.
eLife · Oct 23, 2023Peer-reviewedNeuroscience