Tuan Zea Tan

This study uses spatial transcriptomics to reveal OXPHOS and EMT gradients in ovarian clear cell carcinoma, linking metabolic shifts and LCN2 expression to tumor heterogeneity and outcomes.

This study shows FOXA1 maintains cell polarity and limits lysosome biogenesis in lung adenocarcinoma by regulating transcriptional circuits and interacting with TFE3.

The paper analyzes single-cell expression profiles of circulating tumor cells (CTCs) across cancers, identifies EMT-related patterns, and develops a classifier to recognize CTCs using PBMC transcriptomes.

The paper designs a drug combination to inhibit EMT in a 3D microenvironment by targeting histone deacetylases, SRC, and IKBK, showing effectiveness in a microfluidic model.