Krishan Gupta

Single-Cell Analysis Reveals Critical Role of Macrophage Epsin in Regulating Origin of Foam Cell in Atherosclerosis

This study shows that epsin deletion reduces foam cell formation and rewires vascular smooth muscle cell and endothelial functions in atherosclerosis.

Targeting Liver Epsins Ameliorates Dyslipidemia in Atherosclerosis through Inhibition of Proprotein Convertase Subtilisin/Kexin Type 9-Mediated Low-density Lipoprotein Receptor Degradation

This study shows that targeting liver epsins reduces atherosclerosis by preventing PCSK9-mediated LDLR degradation and improving LDL-C clearance.

Simultaneous visualization of cells and marker genes from scRNA-seq studies

Stardust is a visualization method that embeds cells and marker genes together on a 2D map, performing competitively with existing tools on scRNA-seq and spatial transcriptomics data.

ROSeq: Modeling expression ranks for noise-tolerantdifferential expression analysis of scRNA-Seq data

ROSeq provides a robust differential expression analysis method for scRNA-seq data by modeling expression ranks, showing improved noise tolerance and scalability.

Integrative analysis and machine learning based characterization of single circulating tumor cells

The paper analyzes single-cell expression profiles of circulating tumor cells (CTCs) across cancers, identifies EMT-related patterns, and develops a classifier to recognize CTCs using PBMC transcriptomes.