Morphine analgesia and mu opioid receptor signaling require programed death protein 1 (PD-1)
Zilong Wang, Changyu Jiang, Qianru He, Megumi Matsuda, Qingjian Han, Kaiyuan Wang, Sangsu Bang, Ru‐Rong Ji
This study shows that PD-1 is required for morphine analgesia and MOR signaling in neurons, with PD-L1 enhancing morphine's pain-relieving effects.
bioRxiv · Mar 17, 2019 · PreprintNeuroscience