Colin J. Shew

The paper investigates how cis-regulatory elements in human segmental duplications contribute to expression divergence, finding that duplicated CREs show moderate functional divergence and may drive human-specific regulatory patterns.

A gapless 3.055 billion bp human genome from HiFi and ultra-long nanopore reads resolves all centromeric arrays and acrocentric p-arms, adding 182 Mbp of new sequence.

The paper presents a comprehensive analysis of fully assembled human centromeres, revealing their architecture, variation, and evolutionary dynamics at high resolution.

The paper investigates differential expression of human duplicated genes and finds cis-regulatory divergence contributes to novel expression patterns in recent gene duplicates.