Víctor García

The paper evaluates codon optimization approaches for protein expression in E. coli, finding that negative epistasis limits prediction accuracy and that non-proprietary methods can achieve high expression.

The paper investigates the impact of -1 programmed ribosomal frameshifting on codon usage bias indices and finds that corrections for this effect strengthen the translational efficiency hypothesis.

This study uses mathematical modeling to show de novo mutations drive macrolide resistance in M. genitalium, suggesting caution in azithromycin use for urethritis.

The paper shows that multiple beneficial mutations in HIV lead to wavelet-like oscillations in multilocus linkage disequilibrium, which can indicate mutation interference.