Author

D. Chen

Centre for Addiction and Mental HealthORCID 0000-0001-6672-9716Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

D. Chen141 papers

Biology Disciplines

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Genetic & Genomic Medicine· 3

Signature Assays, Organisms & Methods

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Research Focus:GWAS / association mapping· 3 Organism:human· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Marla Mendes de AquinoiD· 3 shared Bhooma ThiruvahindrapuramiD· 2 shared Brett TrostiD· 2 shared Clement MaiD· 2 shared Nelson Bautista SalazariD· 2 shared Stephen W. SchereriD· 2 shared Worrawat EngchuaniD· 2 shared Clarrisa A. BradleyiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Marla Mendes de AquinoORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintJul 27, 2026

Controls-Only Quality Control Metric from Early GWAS Can Attenuate Gene-Sex Interaction Signals in Contemporary Large-Scale Studies

D. Chen, Marla Mendes de Aquino, Clement Ma

The paper introduces SPADE, a QC metric that reduces bias from gene-sex interaction signals in large-scale GWAS by adjusting for sex-specific disease prevalence and preserving informative variants.

DOI 10.64898/2026.07.22.26358697

humanGWAS summary statistics

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Genetic & Genomic MedicinemedRxivPreprintFeb 12, 2026

Genome-Wide Significance Reconsidered: Low-Frequency Variants and Regulatory Networks in Autism

Marla Mendes de Aquino, Worrawat Engchuan, Sydney Thompson…·Elemi Breetvelt

The paper re-evaluates genome-wide significance thresholds for low-frequency variants in autism, identifying novel variants and their functional roles.

2 citations

humanwhole-genome sequencing

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Genetic & Genomic MedicineThe American Journal of Human GeneticsPeer-reviewedDec 19, 2024

Chromosome X-Wide Common Variant Association Study (XWAS) in Autism Spectrum Disorder

Marla Mendes de Aquino, D. Chen, Worrawat Engchuan…·Stephen W. Scherer

This study performs an X chromosome-wide association study (XWAS) in ASD, identifying 59 variants associated with ASD, including novel candidate genes like FGF13.

45 citationstop 1%

humanwhole-genome sequencing

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