Clarrisa A. Bradley

Tau deletion results in sex-dependent modulation of synaptic weakening in rat hippocampus

This study shows that tau deletion enhances synaptic weakening in male rats but not females, revealing sex-dependent effects on synaptic function and actin dynamics.

Genetic variants in DDX53 contribute to Autism Spectrum Disorder associated with the Xp22.11 locus

The paper identifies DDX53 genetic variants in individuals with ASD, showing a link between DDX53 and ASD, and highlights implications for genetic testing and mouse modeling.

Chromosome X-Wide Common Variant Association Study (XWAS) in Autism Spectrum Disorder

This study performs an X chromosome-wide association study (XWAS) in ASD, identifying 59 variants associated with ASD, including novel candidate genes like FGF13.

A recurrent SHANK3 frameshift variant in Autism Spectrum Disorder

The paper identifies a recurrent SHANK3 frameshift variant in Autism Spectrum Disorder, showing de novo mutations and variable expressivity.

PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

The paper shows that LTP in hippocampal synapses can increase AMPA receptor number or conductance, with distinct mechanisms involving CaMKII and PKA.

GSK-3β regulates the synaptic expression of NMDA receptors via phosphorylation of phosphatidylinositol 4 kinase type IIα

The paper investigates how GSK-3β regulates synaptic NMDA receptor expression through phosphorylation of PI4KII in rat hippocampal slices.