Effects of protein interface mutations on protein quality and affinity
Jurrian K. de Kanter, Eva Smorodina, Aygul R. Minnegalieva, Marloes Arts, Lasse M. Blaabjerg, Marina Frolenkova, Puneet Rawat, Lina Wolfram, Helena Britze, Yano Wilke, Lucas Matthias Weissenborn, Laurens H. Lindenburg, Emily Engelhart, Kerry L. McGowan, Ryan Emerson, , Victor Greiff
The paper disentangles protein-interaction and protein-quality effects in antibody-antigen binding using deep mutational scanning and evaluates models for their ability to predict these effects.
bioRxiv · Mar 26, 2026 · PreprintMolecular Biology