Joke Gerarda van Bemmel

The paper disentangles protein-interaction and protein-quality effects in antibody-antigen binding using deep mutational scanning and evaluates models for their ability to predict these effects.

The paper uses single-cell multimodal analyses to show how maternal diabetes alters epigenomic and transcriptomic states in cardiac and craniofacial progenitors, leading to developmental defects.

The paper inverts a topological domain and shows it causes limited gene expression changes but affects inter-domain communication, particularly in Xist expression.