Marloes Arts

EpiRanha identifies epitope similarities using a structure- and residue-aware graph neural network, improving detection of cross-reactive epitopes and off-target interactions.

The paper disentangles protein-interaction and protein-quality effects in antibody-antigen binding using deep mutational scanning and evaluates models for their ability to predict these effects.

This study shows that ubiquitylation of UBQLN2's UBL domain regulates its stability and localization, with implications for proteasomal degradation and ALS.

The paper creates a dataset of antibody-antigen complexes with mutations and evaluates affinity prediction methods, finding that current models poorly predict binding effects compared to empirical methods.