Gladys Y. P. Poon

This study uses single-cell DNA sequencing to analyze preleukemic hematopoietic stem cells and finds pervasive positive selection throughout preleukemic evolution, with selective advantages ranging from 9%-24% per year.

This study uses serial blood samples to analyze pre-cancerous evolutionary dynamics in acute myeloid leukaemia, showing how driver mutations accumulate and drive clonal expansion over decades.