Hamish A J MacGregor

The paper distinguishes germline and somatic TP53 variants using whole-exome data from UK Biobank participants, showing somatic variants dominate cancer risk in middle-aged adults.

The paper investigates whether immunosurveillance affects clonal haematopoiesis by analyzing MHC binding to mutation hotspots in UK Biobank data, finding no evidence of such influence.

This study uses serial blood samples to analyze pre-cancerous evolutionary dynamics in acute myeloid leukaemia, showing how driver mutations accumulate and drive clonal expansion over decades.

The paper analyzes age-related changes in clonal haematopoiesis (CH) using whole exome data from 420,000 UK Biobank participants, finding a deceleration of clonal expansion with age.