GeneticsNature CommunicationsPeer-reviewed
DNA binding analysis of rare variants in homeodomains reveals novel homeodomain specificity-determining residues
Kian Hong Kock, Patrick K. Kimes, Stephen S. Gisselbrecht…·Martha L. Bulyk
The paper analyzes DNA binding effects of 92 human homeodomain mutants, identifying 14 novel specificity-determining residues and highlighting limitations of variant effect prediction tools.
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