Author

Shaokun Shu

Peking UniversityORCID 0000-0001-6839-2782Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Honggen Zhang· 1 shared Lipeng LaiiD· 1 shared Xiangrui GaoiD· 1 shared Zhirun YueiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperBioinformatics

Honggen Zhang

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1 paper

Recent·Most cited

BioinformaticsbioRxivPreprintAug 11, 2026

siDiff: De Novo siRNA Design via Efficacy-Guided Discrete Masked Diffusion

Zhirun Yue, Honggen Zhang, Xiangrui Gao…·Lipeng Lai

siDiff improves siRNA design by combining a diffusion model with an efficacy guidance model, achieving better hit rates and generalization across target genes.

DOI 10.64898/2026.08.11.744092

diffusion modeldrug response / drug discovery

𝕏 PostBluesky