Author

Zhirun Yue

XtalPi (China)ORCID 0009-0005-6357-7995Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Honggen Zhang· 1 shared Lipeng LaiiD· 1 shared Shaokun ShuiD· 1 shared Xiangrui GaoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperBioinformatics

Honggen Zhang

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1 paper

Recent·Most cited

siDiff: De Novo siRNA Design via Efficacy-Guided Discrete Masked Diffusion

Zhirun Yue, Honggen Zhang, Xiangrui Gao, Shaokun Shu, Lipeng Lai

siDiff improves siRNA design by combining a diffusion model with an efficacy guidance model, achieving better hit rates and generalization across target genes.

bioRxiv · Aug 11, 2026 · PreprintBioinformatics