BioinformaticsbioRxivPreprint
scFPC-DE: Robust Differential Expression Analysis Along Single Cell Trajectories via Functional Principal Component Analysis
Ricardo J. López Candelaria, Yu Qian, Fang Chen…·Xing Qiu
scFPC-DE identifies temporally differentially expressed genes along single-cell trajectories by modeling gene expression as functions of pseudotime and using functional principal component analysis to capture shared covariance structures.