Acid-Sensing Ion Channel 1a Deficiency Drives Endocrine Hypertension in Male Mice
Selina M. Garcia, Megan N. Tuineau, Xavier A. DeLeon, Neil D. Detweiler, Shristey Tamang, Nancy Lapp Kanagy, Laura V. González Bosc, Thomas C. Resta, Jay S. Naik, Nikki L. Jernigan
This study shows that ASIC1a deficiency in male mice causes endocrine hypertension through aldosterone excess and sympathetic overactivity, while female mice are unaffected.
The Journal of Physiology · Nov 15, 2025Peer-reviewedPhysiology