BiochemistrybioRxivPreprint
A structural basis for chaperone repression of stress signalling from the endoplasmic reticulum
Lisa Neidhardt, Joanne Tung, Miriam Kuchersky…·Yahui Yan
This study identifies how AGR2 chaperone forms a dimer to repress IRE1β dimerization and suppress the UPR by blocking its activating conformation.
DOI 10.1101/2025.04.14.648677