Kian Fan Chung

LongOmicsTraj provides a topology-based framework to represent and query longitudinal omics trajectories, identifying corticosteroid response genes with temporal patterns across treatment groups.

The paper examines microbiome diversity and immune interactions in airway mucosa of healthy and asthmatic individuals, finding associations between bacterial counts and immune network eigenvectors.

The paper uses a discrete Morse theory clustering algorithm on a TDA network of gene expression data to identify nine molecular phenotypes associated with asthma and glucocorticoid receptor signaling differences.

The paper identifies a corticosteroid-sensitive gene cluster in COPD patients using asthma-derived transcriptomic signatures and links it to mast cell numbers and lung function improvement.