Ian Michael Adcock

LongOmicsTraj provides a topology-based framework to represent and query longitudinal omics trajectories, identifying corticosteroid response genes with temporal patterns across treatment groups.

This study identifies candidate genes for lung function in Drosophila melanogaster through loss-of-function analysis, finding 11 genes involved in epithelial homeostasis and COPD-related gene expression differences.

This paper introduces a photocontrolled biomaterial gel to study biomechanical induction of mucus hypersecretion in human bronchial organoids, showing biomechanical enhancement of Muc5B expression.

The paper establishes international consensus criteria to classify ageing-related pathologies, diseases, and syndromes based on age progression, functional decline, and human evidence.

The paper investigates how IL-33-induced gene expression in Th2 cells depends on IL-1RL1 haplotype and asthma status, finding stronger effects in risk haplotype carriers and a correlation with pauci-granulocytic asthma.

The paper identifies a corticosteroid-sensitive gene cluster in COPD patients using asthma-derived transcriptomic signatures and links it to mast cell numbers and lung function improvement.