Author

Šárka Pospı́šilová

Central European Institute of Technology – Masaryk UniversityORCID 0000-0001-7136-2680Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Boris TichýiD· 2 shared Vojtěch BystrýiD· 2 shared Adam Krejčí· 1 shared Anastasiya Volakhava· 1 shared Christina SternbergiD· 1 shared Daniela ZwolanekiD· 1 shared Desiree Lindner· 1 shared Evangelia StalikaiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCancer Biology

Boris TichýORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 17, 2026

Retrotransposon Activity in Chronic Lymphocytic Leukemia: Associations with RNA Splicing and TP53 Dysfunction

Anastasiya Volakhava, Šárka Pavlová, Lenka Radová…·Karla Plevová

This study investigates the relationship between TP53 dysfunction, LINE-1 retrotransposon activity, and transcriptomic changes in CLL, finding that retrotransposons influence RNA splicing rather than causing DNA damage.

DOI 10.64898/2026.07.16.738931

humanbulk RNA-seq

Cancer BiologyMolecular CancerPeer-reviewedOct 31, 2024

Cell-autonomous GP130 activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment

Christina Sternberg, Martin Raigel, Tanja Limberger…·Lukas Kenner

This study shows that activating GP130 in prostate epithelial cells suppresses tumor growth through senescence and immune activation, suggesting a new therapeutic approach.

17 citations

humanbulk RNA-seq

BioinformaticsBioinformaticsPeer-reviewedJul 12, 2017

GLASS: assisted and standardized assessment of gene variations from Sanger sequence trace data

Karol Pál, Vojtěch Bystrý, Tomáš Reigl…·Nikos Darzentas

GLASS standardizes variant assessment from Sanger sequencing data, providing consistent output aligned with HGVS nomenclature.

11 citations

long-read sequencingstatistical model