Author

Šárka Pavlová

Central European Institute of TechnologyORCID 0000-0003-1528-9743Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Anastasiya Volakhava· 1 shared Hana SvozilováiD· 1 shared Ilgar Mamedov· 1 shared Iva Staniczková ZamboiD· 1 shared Jakub NeradiliD· 1 shared Jan SkodaiD· 1 shared Jaroslav ŠtěrbaiD· 1 shared Karla PlevováiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Anastasiya Volakhava

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 17, 2026

Retrotransposon Activity in Chronic Lymphocytic Leukemia: Associations with RNA Splicing and TP53 Dysfunction

Anastasiya Volakhava, Šárka Pavlová, Lenka Radová…·Karla Plevová

This study investigates the relationship between TP53 dysfunction, LINE-1 retrotransposon activity, and transcriptomic changes in CLL, finding that retrotransposons influence RNA splicing rather than causing DNA damage.

DOI 10.64898/2026.07.16.738931

humanbulk RNA-seq

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Cancer BiologyCellular OncologyPeer-reviewedDec 1, 2024

Dysregulation of the p53 pathway provides a therapeutic target in aggressive pediatric sarcomas with stem-like traits

Lucie Curylova, Iva Staniczková Zambo, Jakub Neradil…·Jan Skoda

This study shows that restoring p53 activity can target aggressive pediatric sarcomas with stem-like traits by inducing apoptosis in cancer cells while sparing healthy cells.

1 citation

mousehuman

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