Hepatic estrogen receptor α is required for stage-specific coupling of liver metabolism and proliferation during pregnancy
Clara Meda, Arianna Dolce, Giacomo Talamazzini, Claes Ohlsson, Fabrizia Carli, Patrizia Infelise, Amalia Gastaldelli, Adriana C. Maggi, Sara Della Torre
This study shows that hepatic estrogen receptor α is essential for stage-specific coordination of liver metabolism and proliferation during pregnancy, with its loss causing metabolic and growth maladaptations.
bioRxiv · Aug 18, 2026 · PreprintPharmacology & Toxicology