Claes Ohlsson

Hypoadiponectinemia does not enhance anxiety-like behaviour in a lean PCOS-like mouse model

This study examines the relationship between adiponectin levels and anxiety-like behavior in PCOS and finds that reduced adiponectin does not exacerbate anxiety in a PCOS-like mouse model.

Hepatic estrogen receptor α is required for stage-specific coupling of liver metabolism and proliferation during pregnancy

This study shows that hepatic estrogen receptor α is essential for stage-specific coordination of liver metabolism and proliferation during pregnancy, with its loss causing metabolic and growth maladaptations.

A transcriptional atlas of the pubertal human growth plate reveals direct stimulation of cartilage stem cells by growth hormone.

This study reveals GH directly stimulates human growth plate stem cell proliferation via TGF{beta} and ERK pathways, offering insights into growth mechanisms and treatment optimization.

Testosterone exposure during fetal masculinization programming window determines the kidney size in adult mice.

The paper shows that fetal testosterone deficiency reduces adult male kidney size in mice by affecting growth pathways.

Cell type-resolved transcriptomic map of skeletal muscle in women with polycystic ovary syndrome

This study creates a single-nuclei transcriptomic atlas of skeletal muscle in women with PCOS, identifying cell-type-specific dysregulation and therapeutic targets.

Disrupted bone microenvironment and immune recovery following total body irradiation in a murine model

This study investigates the effects of total body irradiation on bone microenvironment and immune recovery in a murine model, finding persistent apoptotic cells and TGF-β1 signaling contribute to impaired bone remodeling.

Quantitative Multicolored Deep Imaging of Human Bones Reveals a Composite Osteo-Sinusoidal Niche for Mesenchymal Stromal Cells.

The paper uses a tissue-clearing protocol to spatially map BM-MSCs in human bones, revealing distinct microenvironment features in young and aged bones.

Tartrate-resistant acid phosphatase (TRAP/ACP5) sex-specifically regulates bone maintenance in old mice, but the anabolic effects of mechanical loading is regulated in a sex-independent way

This study shows TRAP regulates sex-specific bone maintenance and mechanical loading responses in old mice, with TRAP-deficiency impairing bone formation in both sexes.

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization

This study uses GWAS and Mendelian randomization to show that lower sclerostin levels increase risk of hypertension, type 2 diabetes, myocardial infarction, and atherogenic lipid profiles.

Genome Wide Association Metanalysis Of Skull Bone Mineral Density Identifies Loci Relevant For Osteoporosis And Craniosynostosis

This study identifies 59 genome-wide significant loci for skull bone mineral density, including four novel loci, and links them to osteoporosis and craniofacial developmental defects.

Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

This study identifies 15 genetic loci associated with muscle weakness in older adults through a large meta-analysis, revealing new pathways linked to aging and health outcomes.

Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures

This paper uses Mendelian Randomization to show that higher circulating sclerostin levels causally reduce bone mineral density and increase fracture risk.

An Atlas of Human and Murine Genetic Influences on Osteoporosis

This paper identifies 518 genetic loci associated with bone mineral density and fracture risk, validates causal genes in mice, and provides insights for osteoporosis drug development.

Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain

This paper conducts a genome-wide meta-analysis of chronic back pain in 158,025 individuals, identifying three genetic loci associated with the condition.