Author

Anna Špačková

Palacký University OlomoucORCID 0000-0001-7142-3092Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:protein sequence· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Research Focus:benchmarking· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Ivana Hutařová VařekováiD· 2 shared Karel BerkaiD· 2 shared Nina KadášováiD· 2 shared Dominik MartinátiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersBioinformatics

Ivana Hutařová VařekováORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintAug 22, 2026

Mapping pathogenic patterns in membrane transporters from the GLUT transporter family

Nina Kadášová, Dominik Martinát, Anna Špačková…·Karel Berka

The paper maps pathogenicity patterns in GLUT transporters by analyzing missense mutations and their structural impact across the family.

DOI 10.64898/2026.06.28.735151

humanprotein sequence

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BioinformaticsBioinformatics AdvancesPeer-reviewedDec 26, 2024

Pathogenicity Patterns in Cytochrome P450 Family

Anna Špačková, Nina Kadášová, Ivana Hutařová Vařeková, Karel Berka

The paper analyzes pathogenicity patterns in human cytochrome P450 proteins using SIFT and AlphaMissense, revealing increased pathogenicity along protein tunnels toward the cofactor binding site.

1 citation

humanprotein sequence

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