Karel Berka

The paper maps pathogenicity patterns in GLUT transporters by analyzing missense mutations and their structural impact across the family.

AlphaFind v2 enables fast, structure-based search across protein structures and domains, using embeddings and US-align for refinement and supporting organism and CATH-based filtering.

The paper analyzes pathogenicity patterns in human cytochrome P450 proteins using SIFT and AlphaMissense, revealing increased pathogenicity along protein tunnels toward the cofactor binding site.

The paper analyzes the secondary structure anatomy of cytochrome P450 proteins using a workflow that identifies equivalent SSE groups and their properties.