Ribosomal dysregulation: A conserved pathophysiological mechanism in human depression and mouse chronic stress.
Xiaolu Zhang, Mahmoud Ali Eladawi, William G. Ryan, Xiaoming Fan, Stephen Prevoznik, Trupti Devale, Barkha Ramnani, Krishnamurthy Malathi, Etienne L. Sibille, Robert Erne McCullumsmith, Toshifumi Tomoda, Rammohan Shukla
This study identifies ribosomal dysregulation as a conserved mechanism in human depression and mouse chronic stress, linking stress-induced changes in ribosomal proteins and pseudogenes to synaptic dysfunction.
PNAS Nexus · Sep 29, 2023Peer-reviewedNeuroscience