William G. Ryan

This study identifies an interoceptive circuit between the subfornical organ and infralimbic cortex that mediates airway inflammation's impact on fear extinction in mice.

The paper characterizes kinase signaling pathways in astrocytes and microglia, revealing cell- and sex-specific activity patterns that differ from transcriptional profiles.

This study shows that low-dose developmental exposure to deltamethrin disrupts molecular pathways related to circadian rhythms and MAP kinase in mouse brains, linking it to ADHD-like behaviors.

This study identifies elevated mRNA expression of AKT isotypes in schizophrenia neurons, suggesting a potential decoupling of transcript and protein levels, with sex-specific differences and involvement of related signaling components.

This paper identifies EGFR inhibitors as potential therapeutics for noise-induced hearing loss using in silico transcriptome-based drug screening and experimental validation in zebrafish and mouse models.

This study shows that developmental exposure to pyrethroid pesticide deltamethrin disrupts brain metabolism in adult male mice, affecting folate, retinol, tryptophan, and dopamine signaling pathways.

This study identifies ribosomal dysregulation as a conserved mechanism in human depression and mouse chronic stress, linking stress-induced changes in ribosomal proteins and pseudogenes to synaptic dysfunction.