Etienne L. Sibille

The paper identifies sex-specific transcriptional differences in specific cell types of the human subgenual anterior cingulate cortex and links them to GPCR signaling differences in mice.

This study links the FREM3 gene to brain and cognitive aging using cross-species evidence from mice and humans, showing reduced brain volume and cognitive performance in Frem3 knockout mice and lower FREM3-GReX associated with reduced brain surface area and cognitive performance in humans.

The paper identifies reduced SST mRNA and depletion of specific upper-layer Sst interneurons in schizophrenia using single-nucleus RNA-seq and spatial transcriptomics.

This study identifies progressive molecular differences in depression across clinical stages using RNA-seq data, revealing shared and distinct pathways and cell-type-specific changes associated with symptom dimensions and therapeutic targets.

This study investigates how acute and chronic stress affect neuronal and astroglial activity and communication in the prefrontal cortex, finding that chronic stress impairs neuron-astroglia coupling and is linked to behavioral deficits.

This study shows that spine loss in depression impairs dendritic signal integration in human cortical microcircuits, leading to greater functional impairment than reduced inhibition alone.

This study predicts optimal 5-PAM doses for depression treatment using simulated EEG data and machine learning models.

This study identifies distinct EEG biomarkers for 5-PAM in rodents, showing specific changes in theta and beta/gamma power compared to diazepam.

The paper develops polygenic risk scores for molecular brain aging and links them to cortical thickness and cognitive performance in older adults.

The paper shows that 5-GABA-A receptor positive allosteric modulation improves neuronal morphology and cognitive function in a mouse model of tauopathy without affecting p-Tau levels.

This study shows that LPS-induced inflammation reduces GABAergic interneuron markers and BDNF in mouse prefrontal cortex and hippocampus, suggesting a link to MDD pathophysiology.

This study shows that extrasynaptic localization of 5GABAARs is critical for their ability to modulate dopamine system function, as shifting them to synaptic locations abolishes the effect of the 5-PAM GL-II-73.

The paper models the effects of 5-PAM on human cortical microcircuits to assess its potential in treating depression and identifies EEG biomarkers for drug efficacy.

This study identifies ribosomal dysregulation as a conserved mechanism in human depression and mouse chronic stress, linking stress-induced changes in ribosomal proteins and pseudogenes to synaptic dysfunction.

This study examines age-related changes in brain structure and cognition in mice, finding volume and network differences associated with maturation and aging.

This study shows that depletion of PFC GFAP+ astroglia induces anhedonia-like behavior, while their activation reverses stress-induced anhedonia, highlighting their role in depression.

This study evaluates the effects of GABAA receptor modulators in a mouse model of chronic stress, showing antidepressant and pro-cognitive effects with neurotrophic benefits.

The paper identifies that somatostatin processing is a vulnerability factor in SST+ neurons under ER stress, linking chronic stress to behavioral deficits.

The paper models human cortical microcircuits to show reduced inhibition in depression impairs stimulus processing by increasing baseline activity and reducing signal-to-noise ratio.

The paper investigates transcriptomic changes in cortical microcircuit cell types under chronic stress and finds coordinated shifts in gene expression patterns associated with altered excitation-inhibition balance.

The paper integrates transcriptomic data with in-silico analyses to identify cellular, molecular, and causal pathways in trait and state depression.

This paper develops a transcriptome-based polygenic risk score (T-PRS) linking depression-related cortical gene expression changes to brain morphology and symptom severity in MDD.

This study shows chronic amygdala hyperactivation in mice increases anxiety and may worsen stress-induced anxiety but does not cause depressive-like behaviors.

This study examines how chronic stress affects behavior and molecular markers in mice, showing gender-specific differences in molecular responses and behavioral outcomes.

The paper investigates genetic overlap between major depression, bipolar disorder, and Alzheimer's disease using GWAS data and identifies shared genetic correlations and pleiotropic genes.

The paper identifies 11 genes consistently differentially expressed in depression-associated studies and highlights sex-specific effects, particularly for MANEA in cerebral cortex regions.

The paper develops a transcriptome-based polygenic risk score (T-PRS) linking depression-related gene expression changes to neural face processing and anhedonia in a non-clinical sample.

This study shows that chronic stress increases neuronal activation in specific brain regions in response to acute stress, which correlates with behavioral deficits in mice.

This study shows that chronic treatment with a 5-GABA-A receptor PAM increases dendritic length, spine count, and density in mice, suggesting potential for reversing age-related cognitive decline.