Author

Timothy S. Little

The Francis Crick InstituteORCID 0000-0001-7166-2181Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:human· 1 Organism:mouse· 1 Organism:rat· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Abigail K Renfree· 1 shared Andrew P. JacksoniD· 1 shared Blandine M. D. Franke-FayardiD· 1 shared Chris J. JanseiD· 1 shared Christiaan van OoijiD· 1 shared Deirdre A Cunningham· 1 shared Franziska Morhing· 1 shared Giulia Pianta· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

Abigail K Renfree

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1 paper

Recent·Most cited

Essential function reflected in the phylodynamics of a multigene family: the pir genes of malaria parasites

Andrew P. Jackson, Deirdre A Cunningham, Lin Lin, Naomi Mara Claro de Oliveira, Séverine Chevalley, Giulia Pianta, Franziska Morhing, Abigail K Renfree, Timothy S. Little, Robert William Moon, Langhorne Jean, Chris J. Janse, Blandine M. D. Franke-Fayard, Christiaan van Ooij

This study investigates the evolutionary dynamics and essential function of pir genes in malaria parasites, identifying pirC1 as critical for blood stage growth and suggesting a role in host cell interaction or nutrient uptake.

bioRxiv · Jan 23, 2026 · PreprintMicrobiology